Endocrine Abstracts

Background/introduction: SUB:Pituitary – Clinical (Generously supported by IPSEN)We have previously shown that GH assessment during a standardized aerobic exercise of moderate intensity is a reliable test with high diagnostic accuracy in predicting severe GH deficiency (GHD) in adult individuals. However, these studies comprised comparably long exercise durations around 60 min or longer. To improve clinical applicability of exercise testing in the diagnosis of GH...

Background: We and others have shown that ectopic lipids are flexible fuel stores in healthy subjects, in patients with type 1 diabetes or with GHD. IMCL are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. It is unclear whether the exercise-induced flexibility of IMCL and IHCL persists until 24 h and whether healthy subjects and patients with GHD behave differently.Methods: Ma...

Introduction: Ectopic lipids are fuel stores in non-adipose tissues (i.e. skeletal muscle (IMCL), liver (IHCL), heart (ICCL)). An aerobic-exercise bout leads to a decrease in IMCL (‘working tissues’), whereas it is not established whether a single but of exercise influences IHCL or ICCL.Increased IMCL and IHCL have been related to impaired insulin action in skeletal muscle and liver. It is hypothesized that fat availability (subcutaneous and vi...

Introduction: Ectopic lipids are fuel stores in non-adipose tissues (i.e. skeletal muscle (IMCL), liver (IHCL), and heart (ICCL)). It is recognized that IMCL can be depleted by physical activity and repleted by dietary fat intake indicating metabolic flexibility. In contrast, preliminary data suggested that aerobic exercise increases IHCL. Data on the acute effect of aerobic exercise on ICCL is scarce.Increased IMCL and IHCL have consistently been relate...